In a dump in the lawless settlement of Scrapyard, far beneath the mysterious space city of Zalem, disgraced cyber-doctor Daisuke Ido makes a strange find: the detached head of a cyborg woman who has lost all her memories. He names her Alita and equips her with a powerful new body, the Berserker. While Alita remembers no details of her former life, a moment of desperation reawakens in her nerves the legendary school of martial arts known as Panzer...

"Zalem has created replicas of Alita to serve as its secret weapon in quelling the Barjack Rebellion--and their final test is to destroy the original! Stunned and disoriented, Alita struggles in battle. Meanwhile, Kaos wages a solitary battle against his own past and father, Desty Nova, and Den readies a giant railway gun that can shoot down Zalem. How will these three battles intertwine, and what will their resolution bring?! At long last, the conclusion...